HCID 14718905, compound → HCID 14718769, compound

HRID 1088324Notes

Reaction equation

HRID 1088324 reaction equation
O1CCCCC1[O:7][CH2:8][C:9]1[C:14]([F:15])=[C:13]([F:16])[C:12]([CH2:17][CH:18]2[CH2:20][C:19]2([Cl:22])[Cl:21])=[C:11]([F:23])[C:10]=1[F:24]>CO.Cl>[Cl:22][C:19]1([Cl:21])[CH2:20][CH:18]1[CH2:17][C:12]1[C:11]([F:23])=[C:10]([F:24])[C:9]([CH2:8][OH:7])=[C:14]([F:15])[C:13]=1[F:16]

Participants

4

Reactant 1

HCID 14718905HCID 14718905, compound

Product 1

HCID 14718769HCID 14718769, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

4-[(2,2-dichlorocyclopropyl)methyl]-2,3,5,6-tetrafluorobenzyl tetrahydropyran-2-yl ether (0.240 g) was heated at the reflux temperature for 3 hours in a mixture of methanol (5 cm3) and 2M hydrochloric acid (1 cm3). The solvent was evaporated under reduced pressure and water removed azeotropically from the sample by heating with toluene (2×10 cm3). The title product (0.15 q) was obtained as an orange oil.

Workup

  1. customThe solvent was evaporated under reduced pressure and water
  2. customremoved azeotropically from the sample
  3. temperatureby heating with toluene (2×10 cm3)

Sources & evidence

ORD record
ord-98a4e163a78c41baaf344c18b4255c54
Source dataset
uspto-grants-1990_10
Patent number
US04962109

Reaction notes

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