HCID 14996562, compound → Cefadroxil hemihydrate

HRID 1088433Notes

Reaction equation

HRID 1088433 reaction equation
[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].CN1CCCC1=[O:32]>C(O)(C)C.CO>[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].[OH2:32]

Participants

4

Reactant 1

HCID 14996562HCID 14996562, compound

Product 1

HCID 67173987Cefadroxil hemihydrate

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3776IsopropanolSolvent

Conditions

Temperature
10 °C

Procedure

Cefadroxil 1-methyl-2-pyrrolidone solvate (30 g) was slurried in a mixture of 110 ml isopropyl alcohol and 40 ml of methanol kept at 45°-48° C. for 100'. After cooling to 10° C. the mixture was filtered, the product washed with acetone and dried at 40° C.

Workup

  1. customkept at 45°-48° C. for 100
  2. filtrationwas filtered
  3. washthe product washed with acetone
  4. customdried at 40° C.

Sources & evidence

ORD record
ord-54f154e43a4e4fd6b4978172d2ee176b
Source dataset
uspto-grants-1990_10
Patent number
US04962195

Reaction notes

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