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HRID1088446

反应详情

EQUATION

反应方程式

HRID 1088446 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)CCCOc1cccc(C=O)c1
HCID10466631

Butanoic acid, 4-(3-formylphenoxy)-, ethyl ester

C13H16O4

结构：Cc1ccc2ccc(Br)cc2n1
HCID12332896

7-Bromo-2-methylquinoline

C10H8BrN

PRODUCTS

生成物

1
结构：CCOC(=O)CCCOc1cccc(C=Cc2ccc3ccc(Br)cc3n2)c1
HCID53654124

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)OC(C)=O
溶剂HCID7918

Acetic anhydride

C4H6O3

PROCEDURE

实验过程

A solution of 7-bromoquinaldine (22 g, 0.1M) and ethyl 4-(3-formylphenoxy)butanoate (20 g) in acetic anhydride (100 ml) was heated at 135° for 34 hours cooled and evaporated. Flash chromatography of the residue using 1:1 ether in hexane as eluant afforded crude adduct. Recrystallization from hexane ethyl acetate afforded the title compound: m.p. 92-93°.

WORKUP

后处理

  1. temperaturecooled
  2. customevaporated
  3. customafforded crude adduct
  4. customRecrystallization from hexane ethyl acetate