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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1088446Generated: November 2, 2026

Ethyl 4-(3-formylphenoxy)butanoate → Ethyl 4-(3-(2-(7-bromoquinolin-2-yl)ethenyl)phenoxy)butyrate

https://huagongshe.com/reaction/1088446

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-(3-formylphenoxy)butanoateHCID 10466631—
Reactant7-Bromo-2-methylquinolineHCID 12332896—
SolventAcetic AnhydrideHCID 7918—
ProductEthyl 4-(3-(2-(7-bromoquinolin-2-yl)ethenyl)phenoxy)butyrateHCID 53654124—

Reaction Steps

A solution of 7-bromoquinaldine (22 g, 0.1M) and ethyl 4-(3-formylphenoxy)butanoate (20 g) in acetic anhydride (100 ml) was heated at 135° for 34 hours cooled and evaporated. Flash chromatography of the residue using 1:1 ether in hexane as eluant afforded crude adduct. Recrystallization from hexane ethyl acetate afforded the title compound: m.p. 92-93°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04962203
Source datasetuspto-grants-1990_10
ORD IDord-c21cad9740eb4d3296b7186bec63de2a
Source noteuspto-grants-1990_10