Potassium Carbonate → HCID 54431305, compound

HRID 1088457Notes

Reaction equation

HRID 1088457 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=3)=[N:9]2)=[CH:4][CH:3]=1.[CH3:21][CH:22](Br)[C:23]([O:25][CH3:26])=[O:24].C([O-])([O-])=O.[K+].[K+]>C(C(C)=O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:15]=[C:16]([CH:17]=[CH:18][CH:19]=3)[O:20][CH:22]([CH3:21])[C:23]([O:25][CH3:26])=[O:24])=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 95576Methyl 2-bromopropionateHCID 54076725HCID 54076725, compound

Product 1

HCID 54431305HCID 54431305, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To the phenol (Example 35, Step 2) (1 g) in methyl ethyl ketone (20 ml) was added methyl DL-2-bromo-propionate (2 g) and K2CO3 (1 g). The mixture was heated overnight at reflux filtered and evaporated. Flash chromatography of the residue using 10% ethyl acetate in hexane afforded the title compound. Recrystallization from ethyl acetate hexane afforded the title compound: m.p. 101°-102°.

Workup

  1. temperatureThe mixture was heated overnight
  2. temperatureat reflux
  3. filtrationfiltered
  4. customevaporated

Sources & evidence

ORD record
ord-60dd706c0b2141d4936677699a7eb3a2
Source dataset
uspto-grants-1990_10
Patent number
US04962203

Reaction notes

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