Sodium Hydroxide → HCID 54080726, compound

HRID 1088458Notes

Reaction equation

HRID 1088458 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:15]=[C:16]([CH:24]=[CH:25][CH:26]=3)[O:17][CH:18]([CH3:23])[C:19]([O:21]C)=[O:20])=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>C1COCC1.C(O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:12]=[CH:13][C:14]3[CH:15]=[C:16]([CH:24]=[CH:25][CH:26]=3)[O:17][CH:18]([CH3:23])[C:19]([OH:21])=[O:20])=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 54431305HCID 54431305, compound

Product 1

HCID 54080726HCID 54080726, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To the compound of Example 54 (0.5 g) in THF (10 ml) and ethanol (20 ml) at room temperature was added sodium hydroxide (2N). The reaction mixture was stirred overnight at room temperature. The solution was evaporated under vacuo and then redissolved in H20. To the resulting solution was added acetic acid (1 ml). The yellow solid was filtered to give the title compound.

Workup

  1. customThe solution was evaporated under vacuo
  2. dissolutionredissolved in H20
  3. additionTo the resulting solution was added acetic acid (1 ml)
  4. filtrationThe yellow solid was filtered

Sources & evidence

ORD record
ord-b12d5515ac124def8492ea4e5f9e024c
Source dataset
uspto-grants-1990_10
Patent number
US04962203

Reaction notes

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