Sodium Hydroxide → HCID 22163105, compound

HRID 1088468Notes

Reaction equation

HRID 1088468 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH:24]=[CH:25][CH:26]=3)[O:17][CH:18]([CH3:23])[C:19]([O:21]C)=[O:20])=[N:9]2)=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH:24]=[CH:25][CH:26]=3)[O:17][CH:18]([CH3:23])[C:19]([OH:21])=[O:20])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22163065HCID 22163065, compound

Product 1

HCID 22163105HCID 22163105, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of the ester (Step 3) (861 mg), methanol (13 mL) and 5N sodium hydroxide (0.54 mL) was heated under reflux for 2 hours. The reaction mixture was evaporated to approximately 4 mL and acidified to pH 4.5 with HCl (0.5N). This gave a gum which crystallized in methanol to give the title compound. mp 178°

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customThe reaction mixture was evaporated to approximately 4 mL
  4. customThis gave a gum which
  5. customcrystallized in methanol

Sources & evidence

ORD record
ord-8c3df7408c4e44a9a7bf0853296d4bbe
Source dataset
uspto-grants-1990_10
Patent number
US04962203

Reaction notes

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