HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1088471Generated: October 26, 2026
Hydrochloric Acid → 3-(2-(7-Chloroquinolin-2-yl)cyclopropyl)phenol
https://huagongshe.com/reaction/1088471
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanethiol | HCID 6343 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 3-(2-(7-Chloroquinolin-2-yl)cyclopropyl)anisole | HCID 22163093 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran ethyl acetate | HCID 21939870 | — |
| Product | 3-(2-(7-Chloroquinolin-2-yl)cyclopropyl)phenol | HCID 22163090 | — |
Reaction Steps
To the cyclopropylanisole (from Step 2) (1.478 g, 4.77 mmoles) in 20 mL CH2Cl2 at -10° C. was added AlCl3 (1.915 g, 3 eg.) and ethanethiol (1.2 mL, 3.3 eg.). The temperature was raised to 0° C. for 2 hours. Then 10% HCl and THF: EtOAc (1:1) were added and the mixture was stirred and heated until the resulting gum was solubilized. After separation of the phases and extractions with THF:EtOAc (1:1), flash chromatography using 5% EtOAc in toluene yielded the title phenol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04962203 |
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| Source dataset | uspto-grants-1990_10 |
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| ORD ID | ord-18322f49d8ab44d6a2a48ea3d7203243 |
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| Source note | uspto-grants-1990_10 |
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