反应详情

温度

0 °C

To the cyclopropylanisole (from Step 2) (1.478 g, 4.77 mmoles) in 20 mL CH2Cl2 at -10° C. was added AlCl3 (1.915 g, 3 eg.) and ethanethiol (1.2 mL, 3.3 eg.). The temperature was raised to 0° C. for 2 hours. Then 10% HCl and THF: EtOAc (1:1) were added and the mixture was stirred and heated until the resulting gum was solubilized. After separation of the phases and extractions with THF:EtOAc (1:1), flash chromatography using 5% EtOAc in toluene yielded the title phenol.

1. temperatureheated until the resulting gum
2. customAfter separation of the phases and extractions with THF:EtOAc (1:1), flash chromatography