Hydrochloric Acid → HCID 10702167, compound

HRID 1088553Notes

Reaction equation

HRID 1088553 reaction equation
C1O[C:4]2([CH2:8][CH2:7][CH2:6][CH:5]2[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[O:3]C1.Cl.[OH-].[K+]>>[N:10]1([CH2:9][CH:5]2[CH2:6][CH2:7][CH2:8][C:4]2=[O:3])[CH:14]=[CH:13][N:12]=[CH:11]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 108460441-(1,4-Dioxaspiro[4.4]non-6-ylmethyl)-1H-imidazole

Product 1

HCID 10702167HCID 10702167, compound

Conditions

Temperature
60 °C

Procedure

In an oil bath, 3.5603 g of 2-(1H-imidazol-1-ylmethyl)cyclopentanone ethyleneketal (IV) and 17.8 ml of 2N hydrochloric acid added thereto were stirred at 60° C. for 5 hours. The resultant reaction solution was left cooling. Then, it was neutralized with an aqueous 1N potassium hydroxide solution and extracted with methylene chloride, to obtain an organic layer. This organic layer was washed with water, dried over anhydrous sodium sulfate, and evaporated under a reduced pressure.

Workup

  1. customThe resultant reaction solution
  2. waitwas left
  3. temperaturecooling
  4. extractionextracted with methylene chloride
  5. customto obtain an organic layer
  6. washThis organic layer was washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customevaporated under a reduced pressure

Sources & evidence

ORD record
ord-bdaa72f6b4da4d449efd381e9bf2f583
Source dataset
uspto-grants-1990_10
Patent number
US04962278

Reaction notes

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