2-Amino-4,6-dimethoxypyrimidine → HCID 15616170, compound

HRID 1088585Notes

Reaction equation

HRID 1088585 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.[N:12]([S:15]([O:18][C:19]1[CH:30]=[CH:29][CH:28]=[CH:27][C:20]=1[C:21]([O:23][CH2:24][CH:25]=[CH2:26])=[O:22])(=[O:17])=[O:16])=[C:13]=[O:14]>ClCCl>[CH3:9][O:8][C:6]1[CH:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:13](=[O:14])[NH:12][S:15]([O:18][C:19]2[CH:30]=[CH:29][CH:28]=[CH:27][C:20]=2[C:21]([O:23][CH2:24][CH:25]=[CH2:26])=[O:22])(=[O:17])=[O:16])[N:7]=1

Participants

4

Reactant 2

HCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 14480896HCID 14480896, compound

Product 1

HCID 15616170HCID 15616170, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

1.55 g (0.01 mole) of 2-amino-4,6-dimethoxypyrimidine are dissolved in 100 ml of dichloromethane, and 3.40 g (0.012 mole) of allyl 2-isocyanatosulfonyloxybenzoate, dissolved in 20 ml of dichloromethane, are added at 0° C. The mixture is stirred at room temperature for 18 hours and filtered off with suction, and 2.54 g (58% of theory) of allyl 2-[3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyloxy]-benzoate of melting point 110°-112° C. are obtained.

Workup

  1. additionare added at 0° C
  2. filtrationfiltered off with suction, and 2.54 g (58% of theory) of allyl 2-[3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyloxy]-benzoate of melting point 110°-112° C.
  3. customare obtained

Sources & evidence

ORD record
ord-63adf52ad42342ecb53f917e073723fc
Source dataset
uspto-grants-1990_10
Patent number
US04963180

Reaction notes

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