反应详情

Three grams of the obtained (S)-2-fluorooctane-1-ol, 4.5 g of p-toluenesulfonyl chloride and 50 ml of pyridine were stirred at room temperature. 100 ml of water and 200 ml of toluene were added to the solution. The organic layer was separated and washed with an acid solution, with an alkali solution and with water, dried over magnesium sulfate, and concentrated. 6.0 g of (S)-2-fluoro-1-p-toluenesulfonyloxyoctane was obtained.

1. customThe organic layer was separated
2. washwashed with an acid solution, with an alkali solution and with water
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated