Sodium Bicarbonate → HCID 178475888, compound

HRID 1088644Notes

Reaction equation

HRID 1088644 reaction equation
Cl.[NH:2]=[C:3]1[NH:7][C:6]([C:8](=[N:29][OH:30])[C:9]([NH:11][CH:12]2[C:27](=[O:28])[N:14]3[C:15]([C:24]([OH:26])=[O:25])=[C:16]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[CH2:17][S:18][C@H:13]23)=[O:10])=[CH:5][S:4]1.C(=O)([O-])O.[Na+:35]>O>[NH:2]=[C:3]1[NH:7][C:6]([C:8](=[N:29][OH:30])[C:9]([NH:11][CH:12]2[C:27](=[O:28])[N:14]3[C:15]([C:24]([O-:26])=[O:25])=[C:16]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[CH2:17][S:18][C@H:13]23)=[O:10])=[CH:5][S:4]1.[Na+:35]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 178475887HCID 178475887, compound

Product 1

HCID 178475888HCID 178475888, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

In a solution of 0.2 g sodium hydrogen carbonate in 4 ml of water was dissolved 0.619 g of 7-[2-(2-imino-4-thiazolin-4-yl)-2-hydroxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid hydrochloride. The solution was subjected to column chromatography on dextran gel (Sephadex LH-20, Pharmacia), development being carried out with water. The fractions containing the desired product were pooled and lyophilized. By the above procedure there was obtained 0.42 g of the captioned compound.

Sources & evidence

ORD record
ord-b0aef1f9c09541b5a246c45248983745
Source dataset
uspto-grants-1990_10
Patent number
US04963542

Reaction notes

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