Sodium Bicarbonate → HCID 178482019, compound

HRID 1088650Notes

Reaction equation

HRID 1088650 reaction equation
Br.[NH:2]=[C:3]1[NH:7][C:6]([C:8](=[N:32][OH:33])[C:9]([NH:11][CH:12]2[C:30](=[O:31])[N:14]3[C:15]([C:27]([OH:29])=[O:28])=[C:16]([CH2:19][S:20][C:21]4[N:25]([CH3:26])[N:24]=[N:23][N:22]=4)[CH2:17][S:18][C@H:13]23)=[O:10])=[CH:5][S:4]1.C(=O)([O-])O.[Na+:38]>O>[NH:2]=[C:3]1[NH:7][C:6]([C:8](=[N:32][OH:33])[C:9]([NH:11][CH:12]2[C:30](=[O:31])[N:14]3[C:15]([C:27]([O-:29])=[O:28])=[C:16]([CH2:19][S:20][C:21]4[N:25]([CH3:26])[N:24]=[N:23][N:22]=4)[CH2:17][S:18][C@H:13]23)=[O:10])=[CH:5][S:4]1.[Na+:38]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 178419589HCID 178419589, compound

Product 1

HCID 178482019HCID 178482019, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

In a solution of 0.168 g of sodium hydrogen carbonate in 4 ml of water was dissolved 0.578 g of 7-[2-(2-imino-4-thiazolin-4-yl)-2-hydroxyimino-acetamido]-3-(1-methyl-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid hydrobromide. The solution was subjected to column chromatography on dextran gel (Sephadex LH-20, Pharmacia), development being carried out with water. The fractions including the desired product were pooled and lyophilized. By the above procedure there was obtained 0.267 g of the captioned compound.

Sources & evidence

ORD record
ord-0e665b6db2cc416387e490ef15067f8e
Source dataset
uspto-grants-1990_10
Patent number
US04963542

Reaction notes

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