Sodium Bicarbonate → HCID 178475888, compound

HRID 1088652Notes

Reaction equation

HRID 1088652 reaction equation
Cl.C(CC([N:8]=[C:9]1[NH:13][C:12]([C:14](=[N:35][O:36]C(=O)C)[C:15]([NH:17][CH:18]2[C:33](=[O:34])[N:20]3[C:21]([C:30]([OH:32])=[O:31])=[C:22]([CH2:25][O:26][C:27](=[O:29])[CH3:28])[CH2:23][S:24][C@H:19]23)=[O:16])=[CH:11][S:10]1)=S)(=N)N.C(=O)([O-])O.[Na+:44]>O>[NH:8]=[C:9]1[NH:13][C:12]([C:14](=[N:35][OH:36])[C:15]([NH:17][CH:18]2[C:33](=[O:34])[N:20]3[C:21]([C:30]([O-:32])=[O:31])=[C:22]([CH2:25][O:26][C:27](=[O:29])[CH3:28])[CH2:23][S:24][C@H:19]23)=[O:16])=[CH:11][S:10]1.[Na+:44]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 178475889HCID 178475889, compound

Product 1

HCID 178475888HCID 178475888, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In 20 m of water there was suspended 0.525 g of 7-[2-(2-amidinothioacetylimino-4-thiazolin-4-yl)-2-acetoxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid hydrochloride (syn-isomer), followed by the addition of 0.252 g of sodium hydrogen carbonate. The mixture was stirred at room temperature for 15 hours. The reaction mixture, as such was subjected to column chromatography on polystyrene resin (Amberlite XAD-2, Rohm and Haas Co.) and the fractions containing the desired product were pooled and lyophilized.

Sources & evidence

ORD record
ord-e687178d1bc34c6a955ec79209866a94
Source dataset
uspto-grants-1990_10
Patent number
US04963542

Reaction notes

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