Sodium Hydroxide → HCID 10379072, compound

HRID 1088670Notes

Reaction equation

HRID 1088670 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][C:5]([C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[C:4]([C:19]([F:22])([F:21])[F:20])[N:3]=1.[OH-].[Na+]>CO>[NH2:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]([C:13]2[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=2)=[C:4]([C:19]([F:22])([F:20])[F:21])[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9995587HCID 9995587, compound

Product 1

HCID 10379072HCID 10379072, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of the product of part (c), 10% aqueous sodium hydroxide (75 ml) and 125 ml methanol was stirred at 100° C. for 6 hours. The reaction mixture was concentrated in vacuo and the residue neutralized with dilute acetic acid to pH 4-5. The solid product was collected, washed with water and dried to give 12.08 g of 2-amino-5-(4-pyridinyl)-6-trifluoromethyl-3-pyridinecarboxylic acid as a colorless solid, m.p. above 283° C.(decompn.).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe solid product was collected
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-d90ca8a5023a40b6a4f82f03b00b9359
Source dataset
uspto-grants-1990_10
Patent number
US04963561

Reaction notes

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