Sodium Hydroxide → HCID 10379072, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the product of part (c), 10% aqueous sodium hydroxide (75 ml) and 125 ml methanol was stirred at 100° C. for 6 hours. The reaction mixture was concentrated in vacuo and the residue neutralized with dilute acetic acid to pH 4-5. The solid product was collected, washed with water and dried to give 12.08 g of 2-amino-5-(4-pyridinyl)-6-trifluoromethyl-3-pyridinecarboxylic acid as a colorless solid, m.p. above 283° C.(decompn.).

Provenance & Evidence