反应详情

温度

185 °C

A mixture of 92.71 g 2-chloro-3-cyano-6-methyl-5-phenylpyridine, 1000 ml concentrated ammonium hydroxide and 400 ml ethanol was heated in an autoclave at 185° C. for 30 hours. The reaction mixture was cooled in ice, neutralized with acetic acid and stirred at room temperature for 2 hours. The solid product was collected, washed with water (800 ml) and a small amount of ethanol, and dried in a vacuum oven at 85° C. to give 75.61 g (82%) of 2-amino-6-methyl-5-phenyl-3-pyridinecarboxylic acid, m.p. 298-300° C.

1. temperatureThe reaction mixture was cooled in ice
2. customThe solid product was collected
3. washwashed with water (800 ml)
4. dry with materiala small amount of ethanol, and dried in a vacuum oven at 85° C.