反应详情

To a stirred mixture of 10.0 g of 4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carbonitrile (prepared as described in U.S. Pat. No. 4,236,005, Ex. 28) in 150 ml of glacial acetic acid, under nitrogen, at ice bath temperature, was added portionwise 4.15 g of sodium cyanoborohydride. The reaction mixture was stirred in the cold for 30 minutes then at room temperature for 21/2 hours. Then about 50 ml of water was added to the reaction mixture. The precipitate was collected by filtration, washed with water and dried in vacuo to give 8.8 g of the desired product, mp 241°-243° C.

1. customprepared
2. customat room temperature
3. custom2 hours
4. filtrationThe precipitate was collected by filtration
5. washwashed with water
6. customdried in vacuo