HCID 12181446, compound → HCID 21806145, compound

HRID 1088704Notes

Reaction equation

HRID 1088704 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]#[C:12][CH2:13][CH2:14][OH:15]>[Pd].C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][CH2:13][CH2:14][OH:15]

Participants

4

Reactant 1

HCID 12181446HCID 12181446, compound

Product 1

HCID 21806145HCID 21806145, compoundYield 96.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-(2-Quinolinyl)-3-butynol (2.53 g) was hydrogenated over pre-reduced 10% palladium on charcoal (50% aqueous paste, 0.6 g) in ethanol (100 ml) at room temperature and pressure. The reaction mixture was filtered through hyflo and evaporated in vacuo to afford the title compound as a colourless semi-solid (2.50 g), t.l.c. (diethyl ether), Rf 0.20.

Workup

  1. filtrationThe reaction mixture was filtered through hyflo
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-cd4512de3e3e47dfae4e0eb64ff01501
Source dataset
uspto-grants-1990_10
Patent number
US04963564

Reaction notes

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