HRID1088762

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID770796

1-(2,6-Dichlorobenzyl)piperazine

C11H14Cl2N2

结构：CC1=C(c2cccc(C(F)(F)F)c2)n2ncc(C#N)c2N(C(=O)CCl)C1

HCID15101085

未命名化合物

PRODUCTS

生成物

结构：CC1=C(c2cccc(C(F)(F)F)c2)n2ncc(C#N)c2N(C(=O)CN2CCN(Cc3c(Cl)cccc3Cl)CC2)C1.Cl

HCID131716671

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

A mixture of 1 g of 4-(chloroacetyl)-7-[3-(trifluoromethyl)phenyl]-4,5-dihydro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile, 1 g of 2,6-dichlorobenzylpiperazine, 600 mg of potassium carbonate and 100 ml of toluene was reacted as described in Example 16, giving the base form of the product, which was converted to the hydrochloride salt by the procedure of Example 97, giving 1.66 g, mp 252°-254° C.

WORKUP

后处理

customwas reacted
customgiving the base form of the product, which
customgiving 1.66 g, mp 252°-254° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fd34d52b5bc544f9bdacaed8d1e78b1b
来源数据集: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04963553
来源说明: uspto-grants-1990_10

反应 SMILES

[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][C:9]([CH3:11])=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:7]2[N:22]=[CH:23][C:24]([C:25]#[N:26])=[C:6]12)=[O:4].[Cl:27][C:28]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[C:29]=1[CH2:30][N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[ClH:1].[Cl:41][C:37]1[CH:38]=[CH:39][CH:40]=[C:28]([Cl:27])[C:29]=1[CH2:30][N:31]1[CH2:32][CH2:33][N:34]([CH2:2][C:3]([N:5]2[CH2:10][C:9]([CH3:11])=[C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:20])([F:19])[F:21])[CH:13]=3)[N:7]3[N:22]=[CH:23][C:24]([C:25]#[N:26])=[C:6]23)=[O:4])[CH2:35][CH2:36]1