Potassium Carbonate → 4-[[4-[(2,6-Dichlorophenyl)methyl]-1-piperazinyl]acetyl]-4.5-dihydro-6-methyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, hydrochloride

HRID 1088762Notes

Reaction equation

HRID 1088762 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][C:9]([CH3:11])=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[N:7]2[N:22]=[CH:23][C:24]([C:25]#[N:26])=[C:6]12)=[O:4].[Cl:27][C:28]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[C:29]=1[CH2:30][N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[ClH:1].[Cl:41][C:37]1[CH:38]=[CH:39][CH:40]=[C:28]([Cl:27])[C:29]=1[CH2:30][N:31]1[CH2:32][CH2:33][N:34]([CH2:2][C:3]([N:5]2[CH2:10][C:9]([CH3:11])=[C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:20])([F:19])[F:21])[CH:13]=3)[N:7]3[N:22]=[CH:23][C:24]([C:25]#[N:26])=[C:6]23)=[O:4])[CH2:35][CH2:36]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 7707961-(2,6-Dichlorobenzyl)piperazineHCID 151010854-(Chloroacetyl)-4,5-dihydro-6-methyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]-pyrimidine-3-carbonitrile

Product 1

HCID 1317166714-[[4-[(2,6-Dichlorophenyl)methyl]-1-piperazinyl]acetyl]-4.5-dihydro-6-methyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, hydrochloride

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 1 g of 4-(chloroacetyl)-7-[3-(trifluoromethyl)phenyl]-4,5-dihydro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile, 1 g of 2,6-dichlorobenzylpiperazine, 600 mg of potassium carbonate and 100 ml of toluene was reacted as described in Example 16, giving the base form of the product, which was converted to the hydrochloride salt by the procedure of Example 97, giving 1.66 g, mp 252°-254° C.

Workup

  1. customwas reacted
  2. customgiving the base form of the product, which
  3. customgiving 1.66 g, mp 252°-254° C.

Sources & evidence

ORD record
ord-fd34d52b5bc544f9bdacaed8d1e78b1b
Source dataset
uspto-grants-1990_10
Patent number
US04963553

Reaction notes

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