Sulfuric Acid → HCID 19756210, compound

HRID 1088764Notes

Reaction equation

HRID 1088764 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[N:7]2[N:21]=[CH:22][C:23]([C:24]#[N:25])=[C:6]12)=[O:4].S(=O)(=O)(O)[OH:27]>>[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[N:7]2[N:21]=[CH:22][C:23]([C:24]([NH2:25])=[O:27])=[C:6]12)=[O:4]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 15100972HCID 15100972, compound

Product 1

HCID 19756210HCID 19756210, compound

Procedure

A mixture of 2 g of 4-(chloroacetyl)-4,5-dihydro-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile and 20 ml of concentrated sulfuric acid was stirred at room temperature for 2 hours, then poured into ice water, stirred, and filtered. The product was washed with water and dried giving 2 g of the desired intermediate,. mp 174°-176°.

Workup

  1. stirringstirred
  2. filtrationfiltered
  3. washThe product was washed with water
  4. customdried

Sources & evidence

ORD record
ord-f4e43c6639bf414785ae16ee4c4f0730
Source dataset
uspto-grants-1990_10
Patent number
US04963553

Reaction notes

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