反应详情

To a solution of 8-acetoxymethylquinoline (12.07 g) in methanol (80 ml) was added an 30% aqueous solution of sodium hydroxide, and the mixture was heated and refluxed for 1.5 hours. After distilling off the methanol, the resulting residue was extracted with chloroform. After drying over anhydrous magnesium sulfate, the solvent was distilled off. The residue was recrystallized from ethyl acetate-n-hexane to give 8-hydroxymethylquinoline (9.21 g).

1. temperaturethe mixture was heated
2. temperaturerefluxed for 1.5 hours
3. distillationAfter distilling off the methanol
4. extractionthe resulting residue was extracted with chloroform
5. dry with materialAfter drying over anhydrous magnesium sulfate
6. distillationthe solvent was distilled off
7. customThe residue was recrystallized from ethyl acetate-n-hexane