Sodium Hydroxide → Quinolin-8-ylmethanol

HRID 1088785노트

반응식

HRID 1088785 반응식
C([O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[CH:13][CH:12]=[CH:11]2)(=O)C.[OH-].[Na+]>CO>[OH:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:15]=1[N:14]=[CH:13][CH:12]=[CH:11]2

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 150531408-Quinolinemethanol,acetate(ester)

생성물 1

HCID 594412Quinolin-8-ylmethanol수율 96.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 8-acetoxymethylquinoline (12.07 g) in methanol (80 ml) was added an 30% aqueous solution of sodium hydroxide, and the mixture was heated and refluxed for 1.5 hours. After distilling off the methanol, the resulting residue was extracted with chloroform. After drying over anhydrous magnesium sulfate, the solvent was distilled off. The residue was recrystallized from ethyl acetate-n-hexane to give 8-hydroxymethylquinoline (9.21 g).

후처리

  1. temperaturethe mixture was heated
  2. temperaturerefluxed for 1.5 hours
  3. distillationAfter distilling off the methanol
  4. extractionthe resulting residue was extracted with chloroform
  5. dry with materialAfter drying over anhydrous magnesium sulfate
  6. distillationthe solvent was distilled off
  7. customThe residue was recrystallized from ethyl acetate-n-hexane

출처 및 근거

ORD 기록
ord-954b08e55d2248718904bd63c0437371
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04963566

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