反应详情

8-Carboxythiomethyl-1-methyl-1,2,3,4-tetrahydroquinoline hydrochloride (27.9 g) and 5-methoxy-o-phenylenediamine (13.8 g) in 4N hydrochloric acid (100 ml) were refluxed for 40 minutes. The reaction mixture was cooled, neutralized with aqueous ammonia and extracted with chloroform. After drying the extract, the solvent was distilled off under reduced pressure and the resulting residue was purified by silica gel column chromatography [eluent:n-hexane-ethyl acetate (4:1)] to give 8-(5-methoxy-2-benzimidazolyl)thiomethyl-1-methyl-1,2,3,4-tetrahydroquinoline (5.0 g).

1. temperatureThe reaction mixture was cooled
2. extractionextracted with chloroform
3. customAfter drying the extract
4. distillationthe solvent was distilled off under reduced pressure
5. customthe resulting residue was purified by silica gel column chromatography [eluent:n-hexane-ethyl acetate (4:1)]