反应详情

20.5 g of 2-acetylaminoindan is added gradually into 200 ml of fuming nitric acid under cooling. After the reaction, the reaction mixture is poured onto 100 g of ice, and the solvent is evaporated from the chloroform extract, and the residue is recrystallized from isopropyl alcohol to give 18.6 g of 2-acetylamino-5-nitroindan.

1. temperatureunder cooling
2. customAfter the reaction
3. customthe solvent is evaporated from the chloroform
4. extractionextract
5. customthe residue is recrystallized from isopropyl alcohol