反应详情

A solution containing 1.9 g of 2-methoxy-6-trifluoromethylphenol and 1.4 g of hexamethylenetetramine in 20 ml of trifluoroacetic acid was refluxed for 1 h. The solvent was removed in reduced pressure, 50 ml of 1 N hydrochloric acid was added to the residue and the solution was extracted with dichloromethane. Most part of the solvent was evaporated in vacuo and petroleum ether was added, whereupon the product crystallized. Yield 0.7 g (32%), m.p. 151°-152° C.

1. temperaturewas refluxed for 1 h
2. customThe solvent was removed in reduced pressure, 50 ml of 1 N hydrochloric acid
3. additionwas added to the residue
4. extractionthe solution was extracted with dichloromethane
5. customMost part of the solvent was evaporated in vacuo and petroleum ether
6. additionwas added, whereupon the product
7. customcrystallized