Ethanol → HCID 73867402, compound

HRID 1089055Notes

Reaction equation

HRID 1089055 reaction equation
CC[CH2:3][C:4]([O:6][C:7]([CH2:9][CH2:10][CH3:11])=[O:8])=O.[CH2:12](O)[CH3:13].[CH2:15]([NH2:17])C>O>[CH3:15][NH:17][C:10]([CH2:11][CH2:12][CH3:13])=[CH:9][C:7]([O:6][CH2:4][CH3:3])=[O:8]

Participants

5

Reactant 3

HCID 702EthanolHCID 6341EthylamineHCID 7798Butyric anhydride

Product 1

HCID 73867402HCID 73867402, compoundYield 89.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 31.64 g(0.2 mol) ethyl butyryl acetate and 5 mol of ethanol is added dropwise over a period of 5 min. to a solution of 38.7 g(0.6 mol) ethylamine (70% in water) and 50 ml of water (exotherm from 28° C. to 33° C. observed). The mixture is stirred at room temperature for 18 hrs. and is extracted with three 100 ml portions of methylene dichloride (MDC). The methylene dichloride extract is dried over magnesium sulfate and concentrated in vacuo to afford 30.7 g(83% yield) of product, a colorless oil.

Workup

  1. extractionand is extracted with three 100 ml portions of methylene dichloride (MDC)
  2. extractionThe methylene dichloride extract
  3. dry with materialis dried over magnesium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-f5c36e8a7f03405787389a255e0df043
Source dataset
uspto-grants-1990_10
Patent number
US04964896

Reaction notes

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