Sodium Hydroxide → HCID 14075318, compound

HRID 1089056Notes

Reaction equation

HRID 1089056 reaction equation
Cl.[CH3:2][N:3]1[C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:12][C:11](=[O:20])[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4]1[CH3:21].[OH-].[Na+]>O>[CH3:2][N:3]1[C:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:12][C:11](=[O:20])[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4]1[CH3:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14075319HCID 14075319, compound

Product 1

HCID 14075318HCID 14075318, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.0 g(0.0065 mol.) of ethyl 1,2-dimethyl-6-phenyl-4-oxonicotinate hydrochloride (see Example 49 below) is dissolved in water and treated with dilute sodium hydroxide (pH adjusted to about 8). The precipitate formed is isolated by vacuum filtration to afford 1.9 g of product, mp 154° C. (MDC/ether recrystallization).

Workup

  1. customThe precipitate formed
  2. customis isolated by vacuum filtration
  3. customto afford
  4. custom1.9 g of product, mp 154° C. (MDC/ether recrystallization)

Sources & evidence

ORD record
ord-c88888abae1e420c8ca8351d4f35c80b
Source dataset
uspto-grants-1990_10
Patent number
US04964896

Reaction notes

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