反应详情

To a stirred mixture of 50 ml of water, 150 ml of ether and 15.0 g of 2-methoxyphenol was added dropwise 12.7 ml of 61% nitric acid, and the mixture was stirred at room temperature for 15 minutes. The ether layer was separated from the aqueous layer and dried over anhydrous sodium sulfate. After the drying agent was filtered off, the solvent was distilled off under reduced pressure. The residue was purified by silica-gel column-chromatography using Wakogel® C-200 [eluent: chloroform-n-hexane (1:1)] to give 4.72 g of 2-methoxy-6-nitrophenol.

1. customThe ether layer was separated from the aqueous layer
2. dry with materialdried over anhydrous sodium sulfate
3. filtrationAfter the drying agent was filtered off
4. distillationthe solvent was distilled off under reduced pressure
5. customThe residue was purified by silica-gel column-chromatography