Hydrochloric Acid → HCID 13231137, compound

HRID 1089110Notes

Reaction equation

HRID 1089110 reaction equation
C([S:4][CH:5]([CH3:23])[C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]([CH3:22])[CH2:17][C:18](=[O:21])[NH:19][N:20]=2)=[CH:11][CH:10]=1)=[O:7])(=O)C.[OH-].[Na+].Cl>CO>[SH:4][CH:5]([CH3:23])[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]([CH3:22])[CH2:17][C:18](=[O:21])[NH:19][N:20]=2)=[CH:13][CH:14]=1)=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22160502HCID 22160502, compound

Product 1

HCID 13231137HCID 13231137, compoundYield 85.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol was dissolved 1.0 g of the compound obtained in Example 31. To this solution was added in a stream of nitrogen 10 ml of 1 N caustic soda solution, and the mixture was reacted for 90 minutes at room temperature. The mixture was made acidic by the addition of 6-N hydrochloric acid to precipitate crystals, which were then collected by filtration and washed with methanol to obtain 750 mg of the end product.

Workup

  1. customthe mixture was reacted for 90 minutes at room temperature
  2. customto precipitate crystals, which
  3. filtrationwere then collected by filtration
  4. washwashed with methanol

Sources & evidence

ORD record
ord-31f5482ea6674b2ba39c2c15ffa86cfe
Source dataset
uspto-grants-1990_10
Patent number
US04965263

Reaction notes

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