3(2H)-Pyridazinone → HCID 13193370, compound

HRID 1089112Notes

Reaction equation

HRID 1089112 reaction equation
C(N[C@H:12]([C:20]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:30]([CH3:36])[CH2:31][C:32](=[O:35])[NH:33][N:34]=2)=[CH:25][CH:24]=1)=[O:21])[CH2:13]C1C=CC=CC=1)(OCC1C=CC=CC=1)=O.N1NC(=[O:43])C=CC=1.CC1C=NNC(=O)C1.C(N[C@H](C(NC1C=CC(C2C(C)CC(=O)NN=2)=CC=1)=O)CC(=O)N)(OCC1C=CC=CC=1)=O>>[OH:43][CH:12]([CH3:13])[C:20]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:30]([CH3:36])[CH2:31][C:32](=[O:35])[NH:33][N:34]=2)=[CH:25][CH:24]=1)=[O:21]

Participants

5

Reactant 4

HCID 681533(2H)-PyridazinoneHCID 13231139HCID 13231139, compoundHCID 13771991HCID 13771991, compoundHCID 21479294HCID 21479294, compound

Product 1

HCID 13193370HCID 13193370, compound

Procedure

A composition which comprises an effective blood pressure depressing, platelet aggregation inhibiting, or myocardial-contraction reinforcing amount of a compound selected from the group consisting of 6-[4-(N-carbobenzoxy-L-phenylalanylamino)-phenyl]-5-methyl -4,5-dihydro-3(2H)-pyridazinone, 6-[4-(L-phenylalanylamino)-phenyl-5-methyl-4,5-dihydro-3(2H)=pyridazinone, 6-]4-(N-carbobenzoxy-L-tryptophylamino)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone, and 6-[4-(N-carbobenzoxy-L-asparaginylamino)-phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone; and a pharmaceutically acceptable carrier.

Sources & evidence

ORD record
ord-dea87970a19a427e87a8d57723a0ad4e
Source dataset
uspto-grants-1990_10
Patent number
US04965263

Reaction notes

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