反应详情

A solution of 7 ml of 3-azaspiro[5.5]undecane and 9.7 ml of acetic anhydride in 19.5 ml of tetrahydrofuran was refluxed for 3 hours. The volatiles were evaporated to a yellow oil which was distilled in a Kugelrohr still giving a yellow oil, BP 90°-100° C./200-atm. The distillate was purified by chromatography on silica gel using 1:1 ethyl acetate:hexanes giving 7.89 g of the desired product as a colorless oil.

1. customThe volatiles were evaporated to a yellow oil which
2. distillationwas distilled in a Kugelrohr
3. customstill giving a yellow oil, BP 90°-100° C./200-atm
4. distillationThe distillate was purified by chromatography on silica gel using 1:1 ethyl acetate