Hydrochloric Acid → HCID 14839596, compound

HRID 1089225Notes

Reaction equation

HRID 1089225 reaction equation
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([S:18][CH2:19][CH3:20])=[C:12]([F:17])[CH:13]=2)[N:8]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>O>[F:17][C:12]1[CH:13]=[C:14]2[C:9](=[N:10][C:11]=1[S:18][CH2:19][CH3:20])[N:8]([C:21]([CH3:23])([CH3:24])[CH3:22])[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:15]2=[O:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14839595HCID 14839595, compound

Product 1

HCID 14839596HCID 14839596, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 0.23 g (0.65 mmoles) of 6-fluoro-7-ethylthio-(1,1-dimethylethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester in 1 mL of water was treated with 1.3 mL of 1N aqueous sodium hydroxide and the mixture was heated under reflux for 45 minutes. The resulting precipitate was acidified with 1 mL of 2N hydrochloric acid, filtered, washed with water and dried in vacuo at 50° C. to give 0.196 g of titled compound. MP 215° C.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 45 minutes
  3. filtrationfiltered
  4. washwashed with water
  5. customdried in vacuo at 50° C.

Sources & evidence

ORD record
ord-92276669a8f147caaf9adf7008530d5b
Source dataset
uspto-grants-1990_10
Patent number
US04965273

Reaction notes

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