Triethylamine → HCID 14814185, compound

HRID 1089252Notes

Reaction equation

HRID 1089252 reaction equation
Cl[C:2]1[C:7]([NH:8][CH:9]=[O:10])=[C:6]([Cl:11])[N:5]=[C:4]([NH:12][CH:13]=[O:14])[N:3]=1.Cl.[CH2:16]([O:19][NH2:20])[CH:17]=[CH2:18].C(N(CC)CC)C>O1CCOCC1>[CH2:16]([O:19][NH:20][C:2]1[C:7]([NH:8][CH:9]=[O:10])=[C:6]([Cl:11])[N:5]=[C:4]([NH:12][CH:13]=[O:14])[N:3]=1)[CH:17]=[CH2:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 3084724O-Allylhydroxylamine hydrochlorideHCID 13989892N-(4,6-dichloro-2-formamido-pyrimidin-5-yl)formamide

Product 1

HCID 14814185HCID 14814185, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 4,6-dichloro-2,5-diformamidopyrimidine (3.75 g, 16 mmol), O-allylhydroxylamine hydrochloride (1.8 g, 16.4 mmol) and triethylamine (9.1 ml, 66 mmol) in dioxan (80 ml) was stirred at 100° C. for 6 hours. The cooled reaction mixture was filtered and evaporated to dryness under reduced pressure. The residue was on silica gel (eluted with chloroform chromatographed methanol, 10:1) and the product recrystallised from chloroform-methanol affording the title compound (2.1 g, 48%), m.p. 170°-181° C. IR: υmax (KBr) 3240, 1705, 1650, 1590, 1570, 1495, 1465, 1420 cm-1. 1H NMR: δH [(CD3)2SO] 4.37 (2H, d, J=6 Hz, CH2ON), 5.28 (2H, m, CH=CH2), 6.00 (1H, m, CH=CH2), 8.17 (1H, s, CHO), 9.30 (1H, s, CHO), 9.45 (1H, br.s, NH), 10.87 (2H, br.s, 2×NH). Found: C, 39.64; H, 3.49; N, 25.34%, M+ 271.0469. C9H10ClN5O3 requires C, 39.79; H, 3.71; N, 25.78%, M+ 271.0469.

Workup

  1. customThe cooled reaction mixture
  2. filtrationwas filtered
  3. customevaporated to dryness under reduced pressure
  4. customthe product recrystallised from chloroform-methanol affording the title compound (2.1 g, 48%), m.p. 170°-181° C

Sources & evidence

ORD record
ord-3986bb7ce7634073a03ec17bd6d4cef5
Source dataset
uspto-grants-1990_10
Patent number
US04965270

Reaction notes

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