Chloride → HCID 15713162, compound

HRID 1089329Notes

Reaction equation

HRID 1089329 reaction equation
[CH3:1][C:2]1([CH3:12])[NH:6][CH2:5][CH:4]([CH2:7][O:8][CH2:9][CH:10]=[CH2:11])[O:3]1.[OH-].[Na+].[Cl:15][CH:16]([Cl:20])[C:17](Cl)=[O:18].[Cl-]>C1C=CC=CC=1>[CH3:1][C:2]1([CH3:12])[N:6]([C:17](=[O:18])[CH:16]([Cl:20])[Cl:15])[CH2:5][CH:4]([CH2:7][O:8][CH2:9][CH:10]=[CH2:11])[O:3]1

Participants

6

Reactant 4

HCID 312ChlorideHCID 6593Dichloroacetyl chlorideHCID 14798Sodium HydroxideHCID 22160876HCID 22160876, compound

Product 1

HCID 15713162HCID 15713162, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a reaction mixture of 25 percent w/v, 34.2 milliliters of 2,2-dimethyl-5-allyloxymethyl oxazolidine solution in 100 milliliters benzene with 4 grams of 50% sodium hydroxide solution, was added dropwise, 7.4 grams of dichloroacetyl chloride. Cooling in an ice bath and vigorous stirring was maintained during the addition of the chloride. Upon completion of the reaction the mixture was washed with water, dried, separated and the organic solvent removed in vacuo. There was obtained 10.0 grams of the title compound, nD30 1.4705. Analytical data supports the structure.

Workup

  1. additionTo a reaction mixture of 25 percent
  2. temperatureCooling in an ice bath
  3. customUpon completion of the reaction the mixture
  4. washwas washed with water
  5. customdried
  6. customseparated
  7. customthe organic solvent removed in vacuo

Sources & evidence

ORD record
ord-d4060b142f50484eb001c1f1adb1b9a4
Source dataset
uspto-grants-1990_10
Patent number
US04965368

Reaction notes

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