Tetrahydrofuran → HCID 15114605, compound

HRID 1089446Notes

Reaction equation

HRID 1089446 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.C1COCC1.[CH2:17]([N:24]=[C:25]=[O:26])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CCOCC>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH:9][C:25]([NH:24][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:26])=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 108164-ChlorobenzohydrazideHCID 76639Benzyl isocyanate

Product 1

HCID 15114605HCID 15114605, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A stirred suspension of 4-chlorobenzoic acid, hydrazide (10.4932 g, 6.1508×10-2 mole) and dry THF (240 mL) was warmed with a heat gun until it was homogenous. To this stirred solution was added benzyl isocyanate (7.8 ml, 6.3×10-2 mole). After stirring overnight at room temperature, the reaction was diluted with ether. The precipitate was collected by filtration, washed with a little ether, and dried by suction Crystallization from ethanol afforded small colorless needles 15.69 g (84%), mp 244°-246° C.

Workup

  1. temperaturewas warmed with a heat gun until it
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with a little ether
  4. dry with materialdried by suction Crystallization from ethanol afforded small colorless needles 15.69 g (84%), mp 244°-246° C.

Sources & evidence

ORD record
ord-a78d7d8f47e34139b7cc4146125bbb36
Source dataset
uspto-grants-1990_10
Patent number
US04966909

Reaction notes

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