反应详情

640 mg of 7-methoxy-4-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline was dissolved in 13 ml of 48% aqueous hydrogen bromide, and the mixture was heated under reflux under an argon gas stream for 3 hours. The reaction solution was cooled, and crystals which separated out were collected, affording 580 mg of 7-hydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide.

1. temperaturethe mixture was heated
2. temperatureunder reflux under an argon gas stream for 3 hours
3. temperatureThe reaction solution was cooled
4. customcrystals which separated out
5. customwere collected