Hydrogen Bromide → HCID 14719561, compound

HRID 1089479Notes

Reaction equation

HRID 1089479 reaction equation
C[O:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([CH:7]([C:14]3[CH:19]=[C:18]([O:20]C)[C:17]([O:22]C)=[CH:16][CH:15]=3)[CH2:8][NH:9][CH2:10]2)=[CH:5][CH:4]=1.[BrH:24]>>[BrH:24].[OH:2][C:3]1[C:12]([CH3:13])=[C:11]2[C:6]([CH:7]([C:14]3[CH:15]=[CH:16][C:17]([OH:22])=[C:18]([OH:20])[CH:19]=3)[CH2:8][NH:9][CH2:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 14719560HCID 14719560, compound

Product 1

HCID 14719561HCID 14719561, compound

Procedure

To 410 mg of 7-methoxy-4-(5,4-dimethoxyphenyl)-8-methyl-1,2,3,4-tetrahydroisoquinoline, was added 8.2 ml of 48% hydrobromic acid, and the mixture was heated under reflux under an argon gas stream for 3 hours. The reaction mixture was cooled, and the crystals which separated out were collected by filtration, giving 410 mg of 7-hydroxy-4-(3,4-dihydroxyphenyl)-8-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux under an argon gas stream for 3 hours
  3. temperatureThe reaction mixture was cooled
  4. customthe crystals which separated out
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-3f86a1f0a4314f9c8d33b33563e4826f
Source dataset
uspto-grants-1990_10
Patent number
US04966904

Reaction notes

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