反应详情

温度

100 °C

A mixture of 67.88 g (0.45 mole) of 5-methyl-7-hydroxytetrazolo[1,5-a]pyrimidine and 300 ml of phosphorus oxychloride was stirred for 1.5 hours in a bath of 100° C. and then concentrated. The residue obtained was dissolved in 600 ml of chloroform, ice-cooled and then washed with water, followed by drying over anhydrous magnesium sulfate to evaporate the solvent. The set residue was collected by filtration with addition of n-hexane and dried to obtain 70.2 g of the title compound (Yield: 92%).

1. concentrationconcentrated
2. customThe residue obtained
3. temperatureice-cooled
4. washwashed with water
5. dry with materialby drying over anhydrous magnesium sulfate
6. customto evaporate the solvent
7. filtrationThe set residue was collected by filtration with addition of n-hexane
8. customdried