反应详情

温度

60 °C

To a solution of 108 g (1.35 mole) of sodium hydrosulfide dissolved in 4 liters of water, 70 g (0.41 mole) of 7-chloro-5-methyltetrazolo[1,5-a]pyrimidine was added and the mixture was heated to 60° C. and stirred for 2.5 hours. The pH of the mixture was adjusted to about 1 with 2N hydrochloric acid under ice-cooling and stirring. The precipitates were collected by filtration and washed with water, isopropanol and then ether, followed by drying, to obtain 64 g of the title compound (Yield: 93%).

1. temperaturecooling
2. stirringstirring
3. filtrationThe precipitates were collected by filtration
4. washwashed with water, isopropanol
5. customby drying