Hydrochloric Acid → HCID 178429725, compound

HRID 1089525Notes

Reaction equation

HRID 1089525 reaction equation
[SH-:1].[Na+].Cl[C:4]1[N:9]2[N:10]=[N:11][N:12]=[C:8]2[N:7]=[C:6]([CH3:13])[CH:5]=1.Cl>O>[SH:1][C:4]1[N:9]2[N:10]=[N:11][N:12]=[C:8]2[N:7]=[C:6]([CH3:13])[CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 28015Sodium hydrosulfideHCID 148526107-Chloro-5-methyltetrazolo[1,5-a]pyrimidine

Product 1

HCID 178429725HCID 178429725, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 108 g (1.35 mole) of sodium hydrosulfide dissolved in 4 liters of water, 70 g (0.41 mole) of 7-chloro-5-methyltetrazolo[1,5-a]pyrimidine was added and the mixture was heated to 60° C. and stirred for 2.5 hours. The pH of the mixture was adjusted to about 1 with 2N hydrochloric acid under ice-cooling and stirring. The precipitates were collected by filtration and washed with water, isopropanol and then ether, followed by drying, to obtain 64 g of the title compound (Yield: 93%).

Workup

  1. temperaturecooling
  2. stirringstirring
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water, isopropanol
  5. customby drying

Sources & evidence

ORD record
ord-bac7cf847617410e9f759754dd299c0e
Source dataset
uspto-grants-1990_10
Patent number
US04966900

Reaction notes

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