Methanol → 3,4-Dihydroxybenzohydrazide

HRID 1089529Notes

Reaction equation

HRID 1089529 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([OH:11])[CH:5]=1.CO.O.[NH2:16][NH2:17]>O>[OH:11][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][C:7]=1[OH:10])[C:3]([NH:16][NH2:17])=[O:2]

Participants

5

Reactant 3

HCID 887MethanolHCID 24654Hydrazine hydrate (1:1)HCID 287064Methyl 3,4-Dihydroxybenzoate

Product 1

HCID 5863003,4-Dihydroxybenzohydrazide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

120 g of 3,4-dihydroxybenzoic acid methyl ester was subjected to reaction with 340 ml of methanol and 340 ml of hydrazine hydrate over 3 days at room temperature. Then 340 ml of water was added thereto and the solvent was evaporated in vacuum. Addition of water and evaporation were repeated twice. Subsequently the product was crystallized from 340 ml of water. m.p. 260° C. (decomposed).

Workup

  1. customthe solvent was evaporated in vacuum
  2. additionAddition of water and evaporation
  3. customSubsequently the product was crystallized from 340 ml of water

Sources & evidence

ORD record
ord-f38bb47922ae49059b9e83853f772339
Source dataset
uspto-grants-1990_10
Patent number
US04966900

Reaction notes

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