Sodium → 9-(1H-imidazol-1-yl)-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine

HRID 1089555Notes

Reaction equation

HRID 1089555 reaction equation
[N:1]1([C:6]2[CH:28]=[CH:27][C:9]3[O:10][CH2:11][CH2:12][N:13](S(C4C=CC(C)=CC=4)(=O)=O)[CH2:14][CH2:15][O:16][C:8]=3[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Na]>CO.N>[N:1]1([C:6]2[CH:28]=[CH:27][C:9]3[O:10][CH2:11][CH2:12][NH:13][CH2:14][CH2:15][O:16][C:8]=3[CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 2

HCID 5360545SodiumHCID 148563589-(1H-Imidazol-1-yl)-4-[(4-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine

Product 1

HCID 148563649-(1H-imidazol-1-yl)-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

In a manner similar to example 1 react 9-(1H-imidazol-1-yl)-4-[(4-methylphenyl)sulfonyl]-3,4,5,6-tetrahydro-2H-1,7,4-benzodioxazonine with sodium in methanol and ammonia to obtain the title compound.

Sources & evidence

ORD record
ord-feb0b05f226844bc9542557f40712798
Source dataset
uspto-grants-1990_10
Patent number
US04966967

Reaction notes

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