反应详情

温度

225 °C

A mixture of 4 tert butyl-4,5,6,7 tetrahydro-5-benzofuranone (1.00 g, 5.2 mmol) and sulfur (0.167 g, 1 equivalent) in a sealable tube is flushed with nitrogen, sealed and heated to 225° C. for 30 minutes. An additional portion of sulfur (0.030 g) is then added and the mixture heated an additional 15 minutes. After cooling the total reaction mixture is taken up in a small portion of methylene chloride and applied directly to a flash silica gel column. Elution with 5% ethyl acetate in hexane gives 4-tert-butyl5-benzofuranol.

1. customis flushed with nitrogen
2. customsealed
3. additionAn additional portion of sulfur (0.030 g) is then added
4. temperaturethe mixture heated an additional 15 minutes
5. temperatureAfter cooling the total reaction mixture
6. washElution with 5% ethyl acetate in hexane