反应详情

温度

67.5 °C

To a three-necked 50 ml round bottom flask equipped with a mechanical stirrer, reflux condenser and an addition funnel topped with a drying tube containing indicating Drierite® were added 2.70 gm (0.0139 mole) of dimethyl terephthalate (ex Aldrich Chemical Co.) and 15 ml of toluene. A solution containing 0.76 gm (0.0136 mole) of potassium hydroxide and 10 ml of methanol was added dropwise to the diester solution. The mixture formed an immediate emulsion. The emulsion was heated to 65-70° C. and soon thereafter a precipitate began to form. After 30 minutes the reaction was complete. The mixture was cooled to room temperature and the solid collected on a Buchner funnel. The filter cake was washed several times with warm toluene and ether; thereupon the cake was dried in a vacuum oven at 60° C. The yield was 2.85 gm (96%).

1. customTo a three-necked 50 ml round bottom flask equipped with a mechanical stirrer
2. temperaturereflux condenser and an addition funnel
3. customtopped with a drying tube
4. additioncontaining
5. customThe mixture formed an immediate emulsion
6. customto form
7. temperatureThe mixture was cooled to room temperature
8. customthe solid collected on a Buchner funnel
9. washThe filter cake was washed several times with warm toluene and ether
10. customthereupon the cake was dried in a vacuum oven at 60° C