Phosphorus oxychloride → HCID 178432280, compound

HRID 1089758Notes

Reaction equation

HRID 1089758 reaction equation
[C:1]([C:4]1[N:5]=[CH:6][N:7]2[C:12]([OH:13])=[C:11]([CH2:14][CH2:15]O)[C:10]([CH3:17])=[N:9][C:8]=12)(=O)[NH2:2].P(Cl)(Cl)([Cl:20])=O>>[Cl:20][CH2:15][CH2:14][C:11]1[C:10]([CH3:17])=[N:9][C:8]2[N:7]([CH:6]=[N:5][C:4]=2[C:1]#[N:2])[C:12]=1[OH:13]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178432286HCID 178432286, compound

Product 1

HCID 178432280HCID 178432280, compound

Procedure

0.17 mol of the compound obtained in Stage A of Example 3, dissolved in 200 ml of phosphorus oxychloride, is brought to 85° C. for one hour 30 minutes. The phosphorus oxychloride is then removed by evaporation under vacuum. 100 ml of water are added and the pH is adjusted to 7 using sodium bicarbonate to crystallize the expected compound. The latter is filtered off.

Workup

  1. customThe phosphorus oxychloride is then removed by evaporation under vacuum
  2. addition100 ml of water are added
  3. customto crystallize the expected compound
  4. filtrationThe latter is filtered off

Sources & evidence

ORD record
ord-a1bff64a3f104ec58719b96b88408190
Source dataset
uspto-grants-1992_01
Patent number
US05079249

Reaction notes

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