Thionyl Chloride → 3-(1-Methylfluoren-9-yl)propionyl Chloride

HRID 1089854Notes

Reaction equation

HRID 1089854 reaction equation
[CH3:1][C:2]1[C:14]2[CH:13]([CH2:15][CH2:16][C:17]([OH:19])=O)[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1.O=S(Cl)[Cl:22]>>[CH3:1][C:2]1[C:14]2[CH:13]([CH2:15][CH2:16][C:17]([Cl:22])=[O:19])[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 150450953-(1-Methylfluoren-9-yl)propionic acid

Product 1

HCID 150450963-(1-Methylfluoren-9-yl)propionyl Chloride

Procedure

3-(1-Methylfluoren-9-yl)propionic acid (2.5 g, 9.9 mmol) was charged with SOCl2 (20 mL, in excess) at room temperature. The reaction mixture was boiled for 2 hr. Excess of thionyl chloride was removed under reduced pressure. The residual oil was used for the next step without further purification.

Workup

  1. customExcess of thionyl chloride was removed under reduced pressure
  2. customThe residual oil was used for the next step without further purification

Sources & evidence

ORD record
ord-f72077c274bc48209040beb6f717b564
Source dataset
uspto-grants-1992_01
Patent number
US05079260

Reaction notes

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