2-Amino-2-methyl-1-propanol → HCID 14476646, compound

HRID 1089906Notes

Reaction equation

HRID 1089906 reaction equation
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[Cl:7][C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](Cl)=[O:11]>ClC(Cl)C.O1CCCC1.ClCCl.O1CCCC1>[Cl:7][C:8]1[C:9]([C:10]([NH:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4])=[O:11])=[CH:13][CH:14]=[CH:15][N:16]=1

Participants

5

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 27745412-Chloronicotinoyl chloride

Product 1

HCID 14476646HCID 14476646, compound

Reagents, catalysts & solvents 2

HCID 21919333Tetrahydrofurane dichloromethaneSolventHCID 21943919HCID 21943919, compoundSolvent

Procedure

134 ml (1.4 mole) of 2-amino 2-methyl propanol are dissolved in 600 ml of a dichloroethane/tetrahydrofuran mixture (85/15 v/v) and the solution is cooled in an ice/sodium chloride bath. 70.4 g (0.4 mole) of 2-chloro nicotinic acid chloride, prepared as described in Example 1 and dissolved in 770 ml of a dichloromethane/tetrahydrofuran mixture (85/15 v/v) are added such that the temperature is maintained at or below 0° C.

Workup

  1. temperaturethe solution is cooled in an ice/sodium chloride bath
  2. additionare added such that the temperature
  3. temperatureis maintained at or below 0° C.

Sources & evidence

ORD record
ord-13bb7d07f0d544f0b2656662bbcf35db
Source dataset
uspto-grants-1992_01
Patent number
US05079363

Reaction notes

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