反应详情

76.8 g (0.336 mole) of 2-chloro 3-(1,1-dimethyl-2-hydroxy-ethyl)aminocarbonyl pyridine are placed in a reaction vessel immersed in a cooling bath (ice+water). 244 ml (3.36 moles) of thionyl chloride are then added so as to maintain the temperature below 20° C.

1. customimmersed in a cooling bath
2. temperatureto maintain the temperature below 20° C.