HCID 14476647, compound → HCID 14476648, compound

HRID 1089908Notes

Reaction equation

HRID 1089908 reaction equation
[Cl:1][C:2]1[C:7]([C:8]([NH:10][C:11]([CH3:15])([CH3:14])[CH2:12]Cl)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1>C[Si](C)(C)N[Si](C)(C)C>[Cl:1][C:2]1[C:7]([C:8]2[O:9][CH2:12][C:11]([CH3:15])([CH3:14])[N:10]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 14476647HCID 14476647, compound

Product 1

HCID 14476648HCID 14476648, compoundYield 77.2%

Reagents, catalysts & solvents 1

HCID 13838HexamethyldisilazaneSolvent

Conditions

Temperature
125 °C

Procedure

24.7 g (0.10 mole) of 2-chloro 3-(1,1-dimethyl-2-chloroethyl)aminocarbonylpyridine, prepared as described in Example 2c, are suspended in hexamethyldisilazane and the suspension is heated at reflux for 6 h (about 125° C.). The excess hexamethyldisilazane is evaporated under reduced pressure and the residue is distilled under high vacuum to give 16.27 g of 2-chloro 3-(4,4-dimethyl 2-oxazolinyl)pyridine.

Workup

  1. temperaturethe suspension is heated
  2. customThe excess hexamethyldisilazane is evaporated under reduced pressure
  3. distillationthe residue is distilled under high vacuum

Sources & evidence

ORD record
ord-a4c5176b98084cbf89a84c6e5483a781
Source dataset
uspto-grants-1992_01
Patent number
US05079363

Reaction notes

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