Hydrogen Bromide → HCID 15021170, compound

HRID 1090010Notes

Reaction equation

HRID 1090010 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([CH2:13][C@@H:14]([C:16]([OH:18])=[O:17])[NH2:15])=[CH:6]2.Br.[OH-].[Na+]>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([CH2:13][C@@H:14]([C:16]([OH:18])=[O:17])[NH2:15])=[CH:6]2

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 15021169HCID 15021169, compound

Product 1

HCID 15021170HCID 15021170, compoundYield 33.4%

Procedure

A mixture of 0.18 g (0.74 mmol) of 3-(6-methoxy-3-quinolyl)alanine and 5.4 mL of 48% hydrobromic acid was stirred at 85°-90° C. overnight. The reaction mixture was cooled to room temperature and neutralized to pH 7.0 with 1N sodium hydroxide solution, then was concentrated under reduced pressure to give a brown solid. After filtration, the solid product was washed with a small amount of cold water and ethyl ether and then was dried in vacuo to give 57.4 mg (33.4%) of the title compound of the formula: ##STR110##

Workup

  1. concentrationwas concentrated under reduced pressure
  2. customto give a brown solid
  3. filtrationAfter filtration
  4. washthe solid product was washed with a small amount of cold water and ethyl ether
  5. customwas dried in vacuo

Sources & evidence

ORD record
ord-4defde53b07c42f9a83f4b52e00f2eb1
Source dataset
uspto-grants-1992_01
Patent number
US05079366

Reaction notes

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